Radioactive Iodide (131I−) Excretion Profiles in Response to Potassium Iodide (KI) and Ammonium Perchlorate (NH4ClO4) Prophylaxis
نویسندگان
چکیده
منابع مشابه
Radioactive Iodide (131I−) Excretion Profiles in Response to Potassium Iodide (KI) and Ammonium Perchlorate (NH4ClO4) Prophylaxis
Radioactive iodide ((131)I-) protection studies have focused primarily on the thyroid gland and disturbances in the hypothalamic-pituitary-thyroid axis. The objective of the current study was to establish (131)I- urinary excretion profiles for saline, and the thyroid protectants, potassium iodide (KI) and ammonium perchlorate over a 75 hour time-course. Rats were administered (131)I- and 3 hour...
متن کاملPBPK model for radioactive iodide and perchlorate kinetics and perchlorate-induced inhibition of iodide uptake in humans.
Detection of perchlorate (ClO4-) in several drinking water sources across the U.S. has lead to public concern over health effects from chronic low-level exposures. Perchlorate inhibits thyroid iodide (I-) uptake at the sodium (Na+)-iodide (I-) symporter (NIS), thereby disrupting the initial stage of thyroid hormone synthesis. A physiologically based pharmacokinetic (PBPK) model was developed to...
متن کاملBis(triphenylphosphoranylidene)ammonium iodide
The title compound, C(36)H(30)NP(2) (+)·I(-), was obtained accidently from crystallization of a reaction mixture containing [(Ph(3)P)(2)N]OH and B(OH)(3), which was contaminated with MeI. There are two independent [(Ph(3)P)(2)N](+) cations and two I(-) anions within the asymmetric unit. The central PNP angles are non-linear [137.6 (2) and 134.4 (2)°] and the phenyl substituents on P centres ado...
متن کاملRelative potencies and additivity of perchlorate, thiocyanate, nitrate, and iodide on the inhibition of radioactive iodide uptake by the human sodium iodide symporter.
The presence of perchlorate (ClO(4) (-)) in some U.S. drinking water supplies has raised concern about potential adverse thyroidal health effects, because ClO(4) (-) is known to competitively inhibit iodide uptake at the sodium iodide symporter (NIS). Humans are nutritionally and environmentally exposed to other competitive inhibitors of iodide uptake, including thiocyanate (SCN(-)) and nitrate...
متن کاملPotassium iodide in bronchial asthma.
Social Class and Serum Uric Acid M. G. Cook, M.B., and others; R. Finn, M.D. .......................... 232 Sudden Death after Exertion M. McCormack, M.B.; D. C. L. Savage, M.R.C.P. ......................... 232 Congenital Anomalies of the Vas Deferens R. E. B. Tagart, F.R.C.S...................233 Warning to Travellers to Tanzania G. H. Robb, M.R.C.P. 233 Exposure and Exhaustion G. A. Ballance...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: International Journal of Environmental Research and Public Health
سال: 2012
ISSN: 1660-4601
DOI: 10.3390/ijerph9082936